Hedgehog-mediated mesenchymal–epithelial interactions modulate hepatic response to bile duct ligation
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چکیده
منابع مشابه
Yes-Associated Protein Regulates the Hepatic Response After Bile Duct Ligation
UNLABELLED Human chronic cholestatic liver diseases are characterized by cholangiocyte proliferation, hepatocyte injury, and fibrosis. Yes-associated protein (YAP), the effector of the Hippo tumor-suppressor pathway, has been shown to play a critical role in promoting cholangiocyte and hepatocyte proliferation and survival during embryonic liver development and hepatocellular carcinogenesis. Th...
متن کاملAdministration of r-VEGF-A prevents hepatic artery ligation-induced bile duct damage in bile duct ligated rats.
The hepatic artery, through the peribiliary plexus, nourishes the intrahepatic biliary tree. During obstructive cholestasis, the nutritional demands of intrahepatic bile ducts are increased as a consequence of enhanced proliferation; in fact, the peribiliary plexus (PBP) displays adaptive expansion. The effects of hepatic artery ligation (HAL) on cholangiocyte functions during cholestasis are u...
متن کاملRegulation of hepatic eNOS by caveolin and calmodulin after bile duct ligation in rats.
In carbon tetrachloride-induced liver cirrhosis, diminution of hepatic endothelial nitric oxide synthase (eNOS) activity may contribute to impaired hepatic vasodilation and portal hypertension. The mechanisms responsible for these events remain unknown; however, a role for the NOS-associated proteins caveolin and calmodulin has been postulated. The purpose of this study is to characterize the e...
متن کاملPreventative and therapeutic effects of perindopril on hepatic fibrosis induced by bile duct ligation in rats.
The aim of this study was to examine the preventative and therapeutic effects of an angiotensin-converting enzyme inhibitor, perindopril, on cholestasis-induced liver fibrosis. Perindopril was administered orally for 21 days immediately after bile duct ligation at a dose of 2 mg/kg in order to evaluate the preventative effects, and for 21 days starting 3 weeks after bile duct ligation at doses ...
متن کاملProphylactic and curative effects of purslane on bile duct ligation-induced hepatic fibrosis in albino rats.
INTRODUCTION Hepatic fibrosis is a common pathological process of chronic liver injury. Oxidative stress and inflammation may have prognostic value in disease progression. OBJECTIVE To examine the implication of both aforementioned factors in hepatic fibrosis progression and whether, the antioxidant effect of various biological active constituents such as phenolic, flavonoids and fatty acids ...
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ژورنال
عنوان ژورنال: Laboratory Investigation
سال: 2007
ISSN: 0023-6837,1530-0307
DOI: 10.1038/labinvest.3700537